Causes of high abnormal prothrombinogen are commonly seen in vitamin K deficiency from various causes, and in cases of primary liver cancer.
Abnormal prothrombinogen is also known as abnormal coagulation factor II. Clinically, increased abnormal prothrombinogen is mainly seen in:
1. When vitamin K is deficient, the human body cannot synthesize normal prothrombin, but only synthesize abnormal prothrombin, so there is a high level of abnormal prothrombin, which can be seen in long-term use of cephalosporin antibiotics, or use of bicuculline anticoagulant, as well as infants and young children with idiopathic vitamin K deficiency, suffering from serious liver diseases.
2. When there is primary liver cancer, due to the abnormal synthesis of prothrombin precursors by cancer cells, the carboxylation of prothrombin precursors is insufficient and a large amount of abnormal prothrombin is produced, so the abnormal prothrombin test is also a marker reflecting hepatocellular carcinoma.
Therefore, if abnormal plasminogen is elevated in the examination, it is necessary to seek further medical treatment to find out the cause of the disease and treat the cause under the guidance of physicians.