The medication to be taken in the morning when waking up with blood in the sputum depends mainly on its etiology. The most common clinical condition is caused by inflammation of the respiratory tract, including pharyngitis, bronchitis, and pneumonia, and the corresponding anti-inflammatory drugs can be chosen to take if necessary. For bacterial infections, amoxicillin clavulanate potassium, cefuroxime, clindamycin, roxithromycin, azithromycin, etc. can be chosen to take. In case of pulmonary tuberculosis caused by Mycobacterium tuberculosis infection, a combination of multiple anti-tuberculosis drugs such as isoniazid, rifampin, ethambutol, pyrazinamide, etc. should be taken in a standardized manner. If it is a malignant tumor in the lung, such as a ruptured bronchial lung cancer with bleeding, appropriate hemostatic drugs can be taken, including vitamin C, vitamin K1, hemostatin, hemostatic aromatic acid, etc. Targeted anti-lung cancer drugs, such as erlotinib and gefitinib, can also be taken, and the necessary surgery and adjuvant therapy of radiotherapy and chemotherapy should be carried out early.