Appendicitis may cause chronic insidious pain in the right lower abdomen. If the patient suffers from chronic appendicitis, in the non-acute phase, recurrent pain in the right lower abdomen may be present, which can be in the same location and is usually mild, but the pain may persist for several years. Chronic appendicitis may be caused by obstruction of the lumen of the appendix, when there is ischemia of the mucosa in the lumen of the appendix and infection by pathogens. Patients diagnosed with chronic appendicitis may undergo surgical treatment such as appendectomy, after which the prognosis is usually favorable. It is recommended that patients with chronic pain in the lower right abdomen should not self-diagnose or self-medicate, but should seek medical attention in a timely manner, under the guidance of the doctor, through imaging tests and other means to clarify what causes chronic pain, and targeted treatment to avoid delaying the condition.