High doses of sleeping pills can lead to weakness, drowsiness, and mental confusion, and in severe cases can even lead to coma and respiratory depression, resulting in death. The clinical treatment should take into account the specific dose of the drug and the clinical assessment of the patient. In mild cases, the clinical symptoms will gradually improve and disappear with the metabolism of the body. However, in severe cases or when the dose exceeds the safe range, patients should be treated with emetic, gastric lavage and related catheterization as soon as possible to reduce the absorption of the drug and alleviate the further deterioration of clinical symptoms. For patients with respiratory depression, central respiratory stimulants may be administered, depending on the patient’s condition, or an artificial airway may be established with mechanical ventilation. In addition, in order to accelerate the metabolism of drugs, appropriate rehydration and diuretic treatment can be given, and if necessary, blood purification treatment can be given, and the patient should be actively prevented and treated for complications.