Ibuprofen extended-release capsules can be taken with amoxicillin. Ibuprofen extended-release capsules and amoxicillin, which have no contraindications in the instructions, can be taken together. The two drugs are not in the same class of drugs, and they work differently. Taking them together will not affect the efficacy of the drug. Ibuprofen extended-release capsules are non-steroidal anti-inflammatory drugs with antipyretic and analgesic effects. It can be used for fever and arthralgia caused by colds. A small number of patients may experience nausea, vomiting, abdominal pain, diarrhea and other adverse reactions. It is forbidden for those who are allergic to other NSAIDs, pregnant and lactating women, and asthma patients who are allergic to aspirin. Amoxicillin is a penicillin antibiotic used for infectious diseases caused by sensitive bacteria. It can act as a bactericide. Common adverse reactions are diarrhea, nausea and rash. It is contraindicated in patients with penicillin allergy and positive penicillin skin test. It is contraindicated in persons with severe rapid-onset hypersensitivity reactions (e.g., anaphylactic reactions) to other -lactam agents (e.g., cephalosporins, carbapenems, monocyclic -lactams). Ibuprofen extended-release capsules can be taken with amoxicillin, under the supervision of a physician, without overdose. Combining the two may increase adverse reactions, such as gastrointestinal reactions like heartburn and acid reflux, and may also lead to an increased probability of allergic reactions. Medications should be taken under the supervision of a physician.