Osteoarthritis of the knee is a non-inflammatory degenerative disease characterized by degeneration and loss of articular cartilage and regeneration of articular margins and subchondral bone due to multiple causative factors. The main clinical manifestations are knee pain, joint stiffness, swelling and restricted movement. The disease belongs to the category of “paralysis” in Chinese medicine, which is a disease in which the wind, cold, damp and heat evil block the meridians and affects the flow of qi and blood, resulting in pain, heaviness, soreness, numbness or unfavorable flexion and extension of the joints, stiffness, enlargement and deformation of the limbs, joints and muscles. Disease diagnosis (1) Symptoms and signs: joint pain and pressure, joint stiffness, joint swelling bone friction sound (sensation), restricted movement, movement disorders, etc. (2)Auxiliary examination: joint space narrowing, bilateral asymmetry, medial narrowing predominant, sclerosis of the bony rim of the lower edge of the cartilage; intercondylar elevation becomes sharp, joint rim hyperplasia, bone redundancy formation; (3)Laboratory tests: blood routine, protein electrophoresis, immune complexes and serum complement are generally in the normal range. Patients with concomitant synovitis may have mildly elevated C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Patients with secondary OA may present with abnormal laboratory tests of the primary disease. Clinical diagnostic criteria ① knee pain most of the time in the last 1 month ② bone friction sound ③ morning stiffness of the knee ≤ 30 min ④ age ≥ 38 years ⑤ bony enlargement A diagnosis of osteoarthritis of the knee can be made if 1, 2, 3, 4, or 1, 2, 5 or 1, 4, 5 are met.