Whether you have type 1 diabetes or type 2 diabetes, controlling blood glucose levels has been one of the core tasks since the beginning. Previously, some large international diabetes studies, such as the UKPDS study, have confirmed the positive effect of intensive glycemic control on the prevention and treatment of complications. 1. Intensive glucose lowering is a “double-edged sword” In the past, we thought that the center of diabetes treatment is to lower blood sugar. Because high blood sugar is the main cause of complications, and aggravate the complications. Therefore, intensive glycemic control, i.e. intensive glucose lowering, has become an important treatment tool. However, as diabetes research has intensified in recent years, there is a growing recognition that intensive glucose lowering also needs to be viewed in two ways. This is because intensive glucose lowering brings benefits as well as risks. First of all, in diabetic patients, especially some elderly patients, too much emphasis on intensive glucose lowering can easily trigger hypoglycemia, which not only brings sudden conditions such as coma, but also, more seriously, can lead to irreversible damage to vital organs, such as the heart, cerebrovascular and kidney. Secondly, patients with diabetes combined with cardiovascular disease, nephropathy, retinopathy, especially those with fundus bleeding need to be careful about intensive glucose lowering. Intensive glucose lowering, especially in this process of blood glucose from very high to very low, such patients may experience aggravation of complications. This problem has been identified in many national and international studies over the last year. In a statement by the American Diabetes Association, the American College of Cardiology Foundation and the American Heart Association on “Intensive Glycemic Control and Prevention of Macrovascular Disease: Analysis of the ACCORD, ADVANCE and VADT Study Results,” they say that in patients with type 1 and type 2 diabetes, intensive glycemic control is beneficial for microvascular and neurological complications. complications. However, intensive glycemic control did not significantly reduce cardiovascular events. The emphasis on lowering blood glucose regardless of the specific circumstances of the diabetic patient not only poses a risk of hypoglycemia, but may also lead to macrovascular complications and is not effective in reducing mortality. 2, according to the individual, dialectical view of intensive glucose lowering Now, we emphasize that blood glucose control needs to be individualized, and intensive glucose lowering should also be different from person to person. Because the identification of intensive glucose lowering is more in line with the actual treatment of diabetic patients. This discriminatory concept is to keep blood glucose at the ideal level, while effectively avoiding hypoglycemia and reducing and delaying the development of some complications. Specifically, firstly, for first-time patients and patients without complications, intensive glucose lowering to keep blood glucose control at or near normal values, thus solving the problem of glucotoxicity brought by high blood glucose, is undoubtedly an effective treatment; secondly, for elderly diabetic patients, especially those over 65 years old, intensive glucose lowering needs to be carefully considered. Considering the physiological and pathological characteristics of the elderly, individualized intensive glucose lowering requires that blood glucose should not be controlled too strictly, and the target value should be slightly higher than the normal value; thirdly, diabetic patients in other age groups but suffering from various complications such as cardiovascular and cerebrovascular diseases need to pay attention to the fact that blood glucose control is not the only indicator, and the complications should be taken into account while lowering blood glucose. Patients with diabetic nephropathy and diabetic retinopathy combined with fundus retinopathy should pay particular attention; fourth, children with diabetes have relatively greater blood sugar fluctuations and are more sensitive to hypoglycemic drugs and insulin. This group also needs to carefully apply intensive glucose lowering; fifth, gestational diabetes patients who insist on achieving the blood sugar standard are prone to hypoglycemia, which will not only cause harm to the mother, but also irreversible harm to the fetus. 3, the combination of Chinese and Western medicine is expected to break through the research “bottleneck” At present, the core of Western medicine treatment is to focus on the use of drugs, to reduce blood sugar as the center of symptomatic treatment. Chinese medicine, on the other hand, emphasizes the overall approach and focuses on the root of the problem. The two have different focuses, one on the “point” and one on the “surface”. Western medicine is effective in lowering sugar, while TCM is effective in improving complications and vital signs. These can be said to be the two directions of diabetes research in the international arena. However, diabetes research has been facing a dilemma: the research investment is huge, but the incidence is increasing year by year, and the results are not significant. We believe that diabetes research should start from the actual needs of patients, i.e., controlling blood glucose while taking into account the improvement of complications and the overall improvement of body functions. It is well known that diabetes is caused by multiple factors, and it can bring about multiple organ damage and multi-system lesions. Therefore, its treatment should also be multi-targeted, taking into account the whole in the focus. From this idea, the synergy of Chinese and Western medicines is undoubtedly a good research breakthrough. This has already been confirmed by clinical studies with proprietary Chinese medicines such as the Anti-thirst Pill. This combination of Chinese and Western medicine can not only effectively control blood sugar, improve blood lipids, microcirculation, pancreatic islet function as well as improve the patient’s own immune function, etc., but also provide good results in chronic complications, especially cardiovascular and cerebrovascular complications, through the overall adjustment of Chinese medicine.