Glimepiride is an oral hypoglycemic drug, usually taken for about 2-3 days, blood glucose levels can be significantly lower than before. Its main pharmacological effect is to promote the body’s residual pancreatic islet cells secretion of insulin, and improve the sensitivity of the surrounding tissues to insulin, so it has a bidirectional effect, and it is a more commonly used drug. Glimepiride is mainly used by young diabetic patients without diabetic nephropathy, and after diet and exercise treatment, the blood sugar still does not reach the standard, at this time, you can use metformin and glimepiride under the guidance of a professional doctor, and the two can be used at the same time, or can be used individually and with other drugs. The use can not only effectively reduce the patient’s fasting blood glucose level, but also have a certain effect on the reduction of postprandial blood glucose. Because glimepiride regulates insulin sensitivity and causes an increase in insulin secretion, patients are prone to hypoglycemia after use. In order to prevent the occurrence of hypoglycemia, during the patient’s application of glimepiride, it is also necessary to regularly monitor the blood glucose level before and after three meals and at night. It is recommended that diabetic patients try to control fasting blood glucose at 7.0-8.0 mmol/L and 2-hour postprandial blood glucose at 7.5-8.5 mmol/L. The better the blood glucose control, the lower the chance of complications. If blood glucose control is not good, it is easy to have all kinds of infections, including bacterial, viral, fungal and mycoplasma infections.