“How should I take my hypoglycemic pills?” “Is it better to take antihypertensive drugs in the morning or at night?” At the consultation window of the pharmacy, there are many patients coming to consult every day. At present, many people are prone to suffer from the “three highs”, i.e. high blood pressure, high blood fat and high blood sugar, due to long-term irregular life and irrational dietary structure. The activity of the human biological clock has a certain pattern, i.e., the cycle of rhythmicity. If patients can grasp this law, understand some of the “three highs” medication some of the conventional use, the correct time to give medication, can improve the rationality of the medication and compliance, give full play to the efficacy of the drug, for the treatment of twice the result with half the effort. The typical blood pressure fluctuation pattern of hypertensive patients has two peaks in a day, i.e. 9-11 a.m. and 18-19 p.m., after which the blood pressure starts to decline slowly and reaches its lowest level at 2-3 a.m. of the next day. Generally, antihypertensive drugs reach the highest blood concentration 2-3 hours after taking the drug. Long-acting antihypertensive drugs, such as amlodipine, Benadryl, and Chlosartan, should be taken once a day at 7:00 a.m. to maintain stable blood pressure. Some antihypertensive drugs should be taken with food to increase the degree of absorption of the drug in the body. For example: Metoprolol, taking the drug with meals can increase the bioavailability of Metoprolol by 40%. Some drugs should be taken on an empty stomach, such as: captopril, because the food in the stomach can make the absorption of the product to reduce 30% -40%, so it is appropriate to take the drug 1 hour before meals. High blood lipid patients, including cholesterol, triglycerides, etc. HMG-CoA reductase is the rate-limiting enzyme in the synthesis of cholesterol in the body, statins can inhibit the activity of the enzyme, thereby blocking the synthesis of cholesterol, due to the cholesterol synthesis of the characteristics of the night increase, so this kind of drugs, such as the daily administration of the drug once, it is appropriate to take in the evening. The mechanism of action of acarbose in patients with hyperglycemia is that it reaches the upper part of the small intestine at the same time with celiac disease, reversibly competes for the inhibition of а glucosidase, thus delaying the degradation of polysaccharides, oligosaccharides or disaccharides in the intestine, slowing down the degradation of glucose from carbohydrates and its absorption into the blood, and lowering the level of postprandial blood glucose. Therefore, the best time to take acarbose is when you start to eat the first mouthful of meal, if you take it before the meal, it can not reach the small intestine at the same time with the meal, which will reduce its efficacy. However, there are drugs that should be taken 30 minutes before a meal, which can improve the efficacy of the drug, such as: Repaglinide, gliquidone, glipizide.