Pericardial fibrous thickening refers to inflammation causing pericardial fibrous hyperplasia, adhesions, and thickening of the endocardium. So, how to prevent pericardial fiber thickening caused by pericarditis? The following is a brief introduction: The principle of prevention is to treat the primary disease, improve symptoms, and remove circulatory disorders. Active control of tuberculosis and HIV epidemic can significantly reduce the incidence of tuberculosis and HIV-related pericarditis; early coronary reperfusion therapy in patients with acute myocardial infarction can reduce the infarct size and incidence of pericarditis; active treatment of various kidney diseases to prevent the development of end-stage nephropathy is the most cost-effective measure to reduce uremic pericarditis. Once acute pericarditis occurs in various diseases, there are no effective measures to prevent its development into pericardial effusion or pericardial fiber thickening from pericardial tamponade. Rheumatic and non-specific pericarditis rarely cause pericardial tamponade and constrictive pericarditis, while tuberculous, septic and radiation-injured pericarditis are more likely to develop into constrictive pericarditis, so early diagnosis and timely treatment are needed to prevent the development of constrictive pericarditis and the resulting thickening of the pericardial fibers.