The possibility of having children with chromosomal abnormalities needs to be analyzed on a couple-by-couple basis and cannot be generalized. If it is a chromosomal polymorphism such as chromosome follower increase, it does not affect pregnancy and can be normal to have children without any increase, decrease or functional abnormality of genetic material. In the case of chromosomal balanced translocation carriers, there is a possibility of recurrent miscarriage due to chromosomal abnormalities in the offspring, but chromosomal screening before embryo transfer can be used to screen out chromosomally normal embryos for transfer and reduce miscarriage due to chromosomal abnormalities in the embryo. In contrast, pregnancy is not recommended if the number of autosomes is abnormal, which can disrupt the genetic balance. Specific genetic counseling should be performed at the hospital. With the development of modern medical technology, some patients with chromosomal abnormalities are able to have normal blood offspring. It is recommended that couples with chromosomal abnormalities should preferably undergo a full physical examination before pregnancy and prepare for conception when the conditions for conception are met. After successful preparation, it is also necessary to strengthen maternity examinations and have regular ultrasound examinations and 3D ultrasound examinations.