Patients who do not have contraindications to Paeoniflorin and Hydroxychloroquine are able to take them together, please follow the doctor’s instructions. Paeonia lactiflora can be used for the treatment of rheumatoid arthritis, the contraindications of the population is not clear; hydroxychloroquine is a 4-aminoquinoline antimalarial drug, with anti-inflammatory, immunomodulation and other effects, can be used for the treatment of rheumatoid arthritis, lupus discoid erythematosus, desiccation syndrome, etc.; should not be used for the allergy to this drug or the 4-aminoquinoline analogues, children under 6 years of age, previous macular degeneration of the eyes and other people. Therefore, patients who do not have the above contraindications can be treated with Paeoniflorin and Hydroxychloroquine together under the supervision of a doctor. Adverse reactions such as soft stools may occur after treatment with Paeoniflorin. Adverse reactions such as macular degeneration, blurred vision, pruritus, alopecia, nausea, diarrhea, abdominal pain, dizziness, vertigo, tinnitus, neuromyopathy, urticaria may occur after taking hydroxychloroquine. Patients who require treatment with Paeonia lactiflora and hydroxychloroquine are advised to use the medication under the supervision of a doctor.