A person’s personality generally does not change after heart replacement surgery, but patients may experience some mood swings after the surgery. Heart transplantation generally refers to heart transplantation surgery, which can be chosen when the human heart becomes diseased or fails to pump blood and deliver oxygen and nutrients to the brain and other parts of the body. A person’s personality is determined by genetic predisposition or living environment. Heart transplantation is just a transplant of an organ, and it usually does not affect a person’s personality after the operation, but after a major surgery a person’s psychology may become fragile, depressed, and sensitive, which may cause short-term emotional fluctuations, but it does not mean that a person’s personality has changed. Heart transplantation is a difficult operation, which needs to be carried out by professional doctors in regular hospitals. After the operation, we should pay attention to the patient’s emotional fluctuations and provide psychological counseling in time.