Possible causes of premature epiphyseal closure include trauma, precocious puberty, heavy exposure to or consumption of foods or drugs containing sex hormones, and so on. 1. Trauma: due to epiphyseal damage caused by trauma to the epiphyseal region, patients may experience premature epiphyseal closure. 2. Precocious puberty: due to genetic and environmental factors, the patient’s secondary sexual characteristics develop earlier, the sex organs mature earlier, and the patient’s epiphysis may close earlier. 3. Large amount of exposure to or consumption of food or drugs containing sex hormones: such as all kinds of health care products, cosmetics containing sex hormones and contraceptive pills, children’s long-term exposure to or large amounts of these substances, may appear to have premature epiphyseal closure. Early epiphyseal closure is recommended to consult a doctor in time to identify the cause of the disease and carry out targeted treatment to avoid adverse effects.