The normal value of indirect bilirubin is 1.7-10.2 μmol/L. If the value reaches 27 μmol/L, whether it is serious or not needs to be evaluated in combination with the clinical symptoms and other indicators of liver function, and the elevated situation means that the body may have hemolytic disease or liver disease, which needs to be analyzed in combination with the clinical symptoms. Indirect bilirubin is also called unconjugated bilirubin, and its elevation is mainly related to hemolytic diseases in the body. After the destruction of red blood cells, a large amount of hemoglobin is converted to indirect bilirubin, which exceeds the liver’s processing capacity. In addition, hemolytic jaundice also causes an increase in indirect bilirubin, and patients usually have yellow skin, yellow sclera, and yellow urine as well. A value of 27 μmol/L may also be associated with liver problems such as acute jaundice hepatitis and acute hepatic necrosis. In the case of hereditary hyperbilirubinemia, such as Gilbert’s syndrome, the prognosis is generally good and no special treatment is needed. For specific cases, it is recommended to go to the corresponding department of the hospital, and improve the relevant examinations and standardize the treatment under the guidance of the doctor.