Cough with yellow pus sputum may be caused by acute respiratory tract infection, bronchial dilatation, sinusitis and other diseases, according to the primary disease to take treatment. 1. Acute respiratory tract infection: it is the most common cause, which can be seen in upper respiratory tract infection or pneumonia and other diseases, related to bacterial infection, can be empirically used cephalosporin antibiotics such as cefixime, etc., and if necessary, according to the results of the allergy to choose the appropriate antibiotics. 2. Bronchial dilatation: the main symptoms are repeated coughing, coughing up yellow pus sputum, sputum can be layered, a small number of patients only have hemoptysis symptoms. The main treatment for patients with bronchiectasis is to control the infection, and drugs such as moxifloxacin can be used. If the cough symptoms are more serious, can be given to the phlegm drugs such as aminoglutethimide and so on. 3. Sinusitis: Sinusitis patients due to excessive nasal purulent secretion, backflow of the nose and throat and other parts of the phenomenon, resulting in coughing and spitting yellow pus sputum, it is appropriate to preferred and adequate use of penicillin antibiotics such as amoxicillin, etc., the nose can be used to promote the sinus of the 1% ephedrine saline nasal drops ventilation and drainage. Cough with yellow pus and sputum may also be caused by other diseases, if the symptoms do not improve or worsen, it is recommended to consult a doctor, improve the examination, and follow the doctor’s instructions for treatment.