It is not clear how long acetaminophen suppositories can be used continuously, but they should not be used for more than 3 days for fever relief and 5 days for pain relief. Acetaminophen suppositories are commonly used in the treatment of fever caused by the common cold and influenza, and can also be used to relieve mild to moderate pain phenomena, such as headache, muscle pain and so on. The duration of continuous use of acetaminophen suppositories needs to be judged according to the condition, but when used as antipyretic medication, the duration of continuous use should not exceed 3 days, and when applied as pain relieving medication, it should not exceed 5 days. Acetaminophen suppositories are administered rectally and should not be taken orally. If the patient is allergic to the components of the drug, the use of the drug is contraindicated to prevent the occurrence of allergic reactions. Some patients may experience adverse reactions such as skin rash, drug fever, granulocytopenia, etc. Long-term use of large quantities of the drug may lead to abnormalities in liver and kidney function, which should be taken seriously. It is recommended that patients follow the doctor’s instructions to apply acetaminophen suppositories, and not to use the drug on their own. If itchy skin, generalized fatigue and other symptoms occur after the use of the drug, it is necessary to stop using the drug and consult a doctor.