The common causes of generalized itchy skin in the elderly include pruritus, lack of lipid dermatitis, systemic diseases, etc. It is necessary to make a clear diagnosis and follow the doctor’s instructions to choose the appropriate medication and treatment. 1. Pruritus: can be treated with topical moisturizers, such as glycerin, etc.; topical antipruritic agents, such as glycerine lotion, containing menthol or camphor ethanol preparation, etc.; can also be treated with topical glucocorticosteroids, such as hydrocortisone cream, dexamethasone cream, etc.; itching is serious, oral antihistamine treatment, such as loratadine, cetirizine, etc.. 2. lack of seborrheic dermatitis: after the diagnosis of this disease, can be used externally emollient milk treatment, such as moisturizing milk, glycerin, etc.; itching is serious, the external use of glucocorticoid preparations, such as mometasone furoate ointment, hydrocortisone ointment, etc.; if necessary, oral antihistamine treatment, such as loratadine, cetirizine, etc.. 3. Systemic diseases: If the elderly have some systemic diseases, such as cirrhosis, ascites, acute chronic renal failure, diabetes mellitus, uremia, etc., prone to generalized itching symptoms, the need for active treatment of the underlying disease, the underlying disease is treated, the itching symptoms will be relieved. Usually can be used externally some antipruritic drug treatment, such as glycerite lotion, zinc oxide ointment. It is recommended that patients according to their own situation, if necessary, go to a regular hospital, clear the cause of the disease, under the guidance of the doctor reasonable treatment, the use of medication, strictly comply with the doctor’s instructions to use medication, do not blindly self-medication.