Pain in the lymph nodes is most commonly caused by a bacterial or viral infection around the lymph nodes, which causes them to ache. If it is a bacterial infection, antibiotics must be applied to eliminate the local inflammation and the pain will be relieved naturally. Commonly used antibiotics are amoxicillin, roxithromycin or cephalosporin antibiotics, which are all more effective. In addition, you can also use heat-clearing and detoxifying Chinese patent medicines to promote the absorption of inflammation in lymph node pain, commonly used blue scutellaria oral solution, Pu Di Lan oral solution, Qing Kai Ling oral solution and Niu Huang Xie Toxin Tablet, etc., the effect is good, and also can be applied externally to anti-inflammatory and pain relief ointment such as Futalin ointment, ibuprofen gel, also has the effect of anti-inflammatory and pain relief. However, if the malignant tumor causes lymph node pain through metastasis, in this case, the application of the above drugs can not relieve pain, and it is necessary to treat the primary disease or through chemotherapy, radiotherapy, in order to alleviate the pain in the lymph nodes.