Usually, normal human urine routine is negative for urine protein. If there is positive urine protein, it may be due to physiological factors, and this condition usually does not require special treatment, and will be gradually relieved after removing the causative factors. It may also be caused by some diseases that damage the kidneys and cause positive urine protein performance. I. Physiological factors when the body is stimulated by cold, pain, or overexertion, strenuous exercise and eating food containing a lot of protein, these factors may stimulate the kidney blood vessels to spasm and congestion, and the permeability of the glomerular filtration membrane increases, then there will be positive urine protein, when these triggers are removed, the proteinuria will return to normal. In addition, some patients will have positive urine protein in upright position and negative urine protein in recumbent position. This condition usually has no organic lesion and usually does not require special treatment and can be reviewed regularly. Second, pathological factors because protein will be absorbed and metabolized in the kidneys, so when nephropathy occurs, it can lead to a decrease in the body’s absorption function of protein, resulting in the appearance of proteinuria, patients can be found positive urine protein when examined, patients will also be accompanied by hematuria, hypothermia, hypertension, edema and other manifestations. Kidney disease can be divided into two types: primary and secondary.1. Primary nephropathy: such as primary acute and chronic nephritis, IgA nephropathy, fibrous glomerulopathy, pyelonephritis, interstitial nephritis, renal cancer, etc. Since there are many causes of kidney disease that can cause positive urine protein, if you suspect the presence of kidney disease, you should seek medical attention in a timely manner and make a comprehensive assessment by combining routine blood, urine, kidney function tests and imaging examinations, usually treated with glucocorticoids, immunosuppressants, etc. If necessary, dialysis is required. If there are organic lesions in the kidney, renal puncture biopsy may also be required to clarify the pathological type; 2. Secondary nephropathy: such as diabetic nephropathy, hypertensive nephropathy, and acute and chronic renal insufficiency or renal failure due to various causes such as systemic lupus erythematosus, AIDS, syphilis, and taking nephrotoxic drugs. At this time, the primary disease should be controlled, such as for hypertensive nephropathy, ACEI or ARB drugs can be used to reduce urinary protein; for diabetic nephropathy, glucose-lowering drugs or insulin should be used to actively control blood sugar, and angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists can be used when there is a large amount of proteinuria; in addition, there are some immune diseases that can lead to an increase in the synthesis of non-albumin in the body, which In addition, there are some immune diseases that can lead to an increase in the synthesis of non-albumin in the body, exceeding the absorption capacity of the kidneys, resulting in proteinuria, such as monoclonal gammopathy and leukemia, which may also lead to an increase in the synthesis of non-albumin, resulting in positive urine protein during urine examination, but this is a rare case, and often requires a combination of urine protein four, blood coagulation, bone marrow aspiration and other more delicate tests to confirm the diagnosis. Third, the other above are some true positive urine protein cases, in addition, positive urine protein may also be a false positive result, consider with the urine mixed with blood, leukorrhea, prostate fluid, semen, or after the lower urinary system infection, such as urethritis, cystitis produced by a variety of inflammatory secretions. Proteinuria is also present in this examination. It is usually necessary to drink a lot of water and promote urination so as to flush the urinary tract and help the discharge of bacteria, in addition to oral quinolones such as levofloxacin, norfloxacin, moxifloxacin, etc. As the positive urine protein points to more possibilities, after the positive urine protein appears, it should be retested and combined with quantitative urine protein test, blood routine, kidney function and many other tests to clarify the test results.