Neither Febuxostat nor Benzbromarone has a better effect, both can be used to control the patient’s blood uric acid level, but there are differences in the indications, mechanism of action and adverse drug reactions, etc., which need to be selected according to the patient’s condition and personal constitution and other factors. 1. Indications: Febuxostat is mainly used for the treatment of hyperuricemia in gout patients, and is generally not recommended for the treatment of hyperuricemia without clinical symptoms; Benzbromarone can be used in addition to the treatment of gouty intervals and gouty nodes can also be used for the treatment of primary and secondary hyperuricemia. 2. Mechanism of action: Febuxostat mainly reduces the production of uric acid and plays the role of lowering uric acid; Benzbromarone mainly promotes the excretion of uric acid and plays the role of lowering the level of uric acid in the blood. 3. Adverse drug reactions: febuxostat common adverse drug reactions for liver function abnormalities, skin rash, nausea and arthralgia; benzbromarone common adverse drug reactions for gastrointestinal discomfort, rubella. Febuxostat is contraindicated in people who are allergic to the components of the drug and those who are receiving azathioprine or mercaptopurine treatment. Benzbromarone is contraindicated in people who are allergic to the components of the drug. People with moderate to severe renal impairment and patients suffering from kidney stones. Pregnant women, women at risk of pregnancy, as well as breastfeeding women. Note that Febuxostat and Benzbromarone can not be used during an acute attack of gout, drink plenty of water during the use of the drug, which facilitates the excretion of uric acid. It is recommended that patients who need to use Febuxostat and Benzbromarone for treatment go to the relevant departments of regular hospitals for detailed consultation.