Pain in the cheeks and ears when biting may be due to temporomandibular joint disorder disease, dental disease, or parotid inflammation, and root canal, medication, or surgery will be needed to identify the cause. 1. Temporomandibular joint disorder: In temporomandibular joint disorder, pain in front of the ear screen and limitation of opening the mouth will occur when teeth bite up and down, which can be treated with moist hot compress, local injection of sodium hyaluronate or surgery. 2. Dental diseases: if there is pulpitis involving lymph nodes or apical periodontitis, there will be pain when biting up and down, and root canal treatment is needed. 3. Inflammation of the parotid gland: Inflammation of the parotid gland can occur when infected, and the parotid gland area can be painful and uncomfortable when biting up and down, using ribavirin for viral infections and penicillin for bacterial infections to carry out anti-infective treatment. Any pain or discomfort in the bite is recommended to consult a doctor as soon as possible to avoid aggravation of symptoms affecting the quality of life, and the use of medication should be in accordance with the doctor’s instructions.