Rheumatoid arthritis is an autoimmune disease with symmetric polyarthritis. Immune system dysfunction is an important pathogenetic mechanism, activated T lymphocytes infiltrate the synovial membrane of the joints leading to synovitis is the main pathological changes, if the synovial membrane of the joints of the whole body is involved in multiple places, there may be pain in multiple places of the whole body. Rheumatoid arthritis is a common connective tissue inflammatory disease. In the early stage of the disease, small joints are swollen and painful with morning stiffness, in the middle stage, there are difficulties in joint function and impaired mobility, and in the late stage, patients may develop joint deformities and be unable to move normally. Rheumatoid arthritis is mainly related to the environment, immunity, genetics and other factors, under the combined effect of these factors, the body’s immune function disorders, abnormal activation of T lymphocytes, the production of autoantibodies and a variety of inflammatory factors, attacking the synovial membrane of the joints of the body to produce inflammation. If the synovial membrane is involved in multiple places throughout the body, pain may occur in multiple places throughout the body. Rheumatoid arthritis patients may have pain in many parts of the body, it is recommended to go to the local regular hospital as soon as possible, according to the diagnosis of the situation of targeted treatment, which is conducive to the control of the development of its condition.