24h urine protein 500mg is abnormal, but not serious, if the active treatment of the disease can be well controlled or cured. 24h urine protein 500mg indicates that the amount of urine protein is more than normal, at this time should check the urine routine, because pathological urine protein (+) – (++) is mostly caused by glomerulonephritis and other diseases. The treatment of glomerulonephritis is to give a kidney puncture, clarify the type of kidney pathology, and choose to apply hormonal immunosuppressive and cytotoxic drugs according to the type of pathology. It can also be treated with the use of proprietary Chinese medicines, such as Huangkui capsule and Nephrolithian Siwei capsule, both of which have the effect of clearing heat and relieving dampness and have been clinically studied to have good therapeutic effect on reducing urine protein.