Closed mouth, i.e. whitehead acne, creams for treating whitehead acne include retinoic acid, benzoyl peroxide gel, azelaic acid cream and so on. 1. Retinoic acid gel: commonly used retinoic acid gels include adapalene gel, tazarotene gel, etc. Topical topical application can be used for the treatment of mild to moderate normal acne with pimples, papules and pustules as the main manifestations. Adverse reactions of skin irritation may occur. 2. Benzoyl peroxide gel: benzoyl peroxide gel can dissolve acne and has astringent effect, can be used to treat acne, may cause contact dermatitis, burning sensation of the skin, itching, redness and other adverse reactions, the skin has acute inflammation and breakouts are prohibited. 3. azelaic acid cream: azelaic acid cream can inhibit the formation of acne, suitable for the local treatment of acne, its adverse reactions are generally mild and transient, including itching, burning, irritation, etc., azelaic acid allergy is prohibited. All ointments for the treatment of whitehead acne should be administered under the guidance of a medical professional, and patients are advised to seek timely medical attention and avoid self-medication.