For the blood sugar control of diabetes, the methods are: reasonable control of diet, appropriate physical exercise, regular monitoring of blood sugar, correct diabetes education, standardized drug therapy, then the more common of drug therapy is oral drug therapy. For oral hypoglycemic drugs, we should not only know how many times a day to take, how many tablets to take at a time; in order to play a good role, while reducing the occurrence of adverse reactions, we should also know the prescribed medication is to eat before meals? During a meal? Or after a meal? Biguanides: including metformin, etc., taken with a meal, that is, swallowed with the meal; or immediately after the meal. Sulfonylureas: These include glimepiride, gliclazide, glipizide, etc. They are usually taken half an hour before a meal. Glimepiride, recommended to be taken shortly before or during breakfast, or shortly before or during the first main meal if breakfast is skipped. Thiazolidinediones: These include pioglitazone, rosiglitazone, etc. They can be taken independently of food, i.e., on an empty stomach, during or after a meal. Glucosidase inhibitors: including acarbose, voglibose, etc. They are chewed during meals or swallowed before meals and eaten immediately after taking the medication. Non-sulfonylurea insulin secretagogues (glinides): including repaglinide, nateglinide, etc., to be taken 0-30 minutes before meals. DPP-4 inhibitors: including alogliptin, sitagliptin, saxagliptin, etc. The time of taking the drug is not affected by meals, which means that the drug can be taken on an empty stomach, during or after a meal.