Patients with pain in the right side of the abdomen at night, there are several common causes: a. Patients with gallbladder stones accompanied by acute cholecystitis, due to the excitement of the vagus nerve at night, the contraction of the gallbladder is frequent, if the stone is embedded in the gallbladder duct, the patient may experience pain and discomfort in the right upper abdomen. At this time, patients can improve the ultrasound or CT examination of liver and gallbladder to clarify the specific condition of the stone, and for patients with recurrent gallbladder stones, surgery is recommended to avoid septic or gangrene-like changes of the gallbladder caused by stone imbedding. For patients with duodenal bulb ulcer, due to the increase of gastric acid secretion at night, more gastric acid will stimulate the ulcer wound of duodenum, thus causing pain in the right side of the abdomen. Patients can improve gastroscopy to clarify the size, volume and location of the ulcer. Some patients can take oral omeprazole, Daxil tablets and colloidal bismuth to promote faster healing of the ulcer wound. In patients with concomitant H. pylori infection, active bacterial killing is required to avoid aggravation of the local ulcer and serious complications such as perforation or bleeding.