For a long time, “ground-glass nodules” have been troubling many people. A study confirms that 95% of lung cancers detected during physical examination are characterized as “ground-glass nodules” in the imaging report. In addition, “ground-glass nodule” lung cancer is increasingly seen in the “low-risk group” of traditional lung cancer. In order to help people better cope with “Ground Glass Nodule”, the team led by Prof. Haiquan Chen has conducted a lot of research on “Ground Glass Nodule” lung cancer. What is “Ground Glass Nodule”? “Ground glass nodules” is a common term used in medical reports. On medical imaging (mainly CT chest), a “ground-glass nodule” appears as a structure that is not the same density as the surrounding lung tissue – it is denser, but the texture of the blood vessels in it can still be seen clearly. A “ground glass nodule” is usually found in the lungs and looks like “ground glass”. Its nature may be inflammation, hemorrhage, precancerous lesions, lung cancer, and so on. Clinically, malignant “ground-glass nodules” are called “ground-glass nodule-type” lung cancer. According to the difference of transparency, it can be divided into pure ground-glass nodules and mixed ground-glass nodules. Pure ground-glass nodules: these lung cancer foci are relatively homogeneous on medical imaging; Mixed ground-glass nodules: these lung cancer foci are “unevenly transparent” and partially opaque on medical imaging. According to the survival statistics of operated patients, the 5-year survival rate of these two types of lung cancer patients can reach 100% and 98.1% respectively, which is very satisfactory. Redefining “Ground Glass Nodular” Lung Cancer A study led by Prof. Haiquan Chen’s team of 736 surgically resected patients with ground glass nodular lung adenocarcinoma showed that patients with ground glass nodular lung adenocarcinoma had a good prognosis, with a 5-year overall survival rate of 98.99%, which was significantly higher than that of the entire population of adenocarcinoma of the lung. The study was published in August 2018 in Annals of Thoracic Surgery, the official journal of the Society of Thoracic Surgeons,STS. Based on this study, Prof. Haiquan Chen’s team conducted another study that included 911 patients with lung adenocarcinoma. The clinicopathological features and prognosis of lung adenocarcinoma patients with “mixed ground-glass nodules” on imaging were further analyzed and compared with the survival data of patients with solid lung adenocarcinoma. Among the postoperative lung adenocarcinoma cases included in the study, there were 329 lung adenocarcinoma patients with “mixed ground-glass nodules” on CT imaging, and the follow-up data showed that the 5-year survival rate of these patients reached 98.13%; compared with the 5-year survival rate of 80.27% of the other solid lung adenocarcinoma patients, the difference between the two was nearly 18%. 18%. The results of this study confirm the initial concept of Prof. Haiquan Chen’s team that mixed ground-glass nodular lung cancer is a special clinical subtype different from solid lung cancer. The results of this study represent a new understanding of mixed ground-glass lung cancer and will help to further rationalize the diagnosis and treatment of patients with this type of lung cancer. The study was published in the Journal of Thoracic Oncology, the official journal of the International Association of Study of Lung Cancer, which is one of the most authoritative journals in the field of lung cancer research in the world, and the latest clinical and pathological staging of lung cancer is published in this journal. The latest clinical and pathologic staging of lung cancer is released globally through this journal. “Surgery is the mainstay of the treatment of ground-glass nodule lung cancer. Surgery is the mainstay of treatment for ground-glass nodules. However, for first-discovered ground-glass nodules, Prof. Haiquan Chen’s team recommends a follow-up period of 4-6 months to reduce the proportion of benign patients who are operated on and to avoid over-treatment. Benign ground-glass nodules usually disappear during the follow-up period. Because of the strict control of surgical indications, 93% of the ground-glass nodules surgically removed by Prof. Haiquan Chen’s team were lung cancer. Patients with “ground-glass nodule” lung cancer are often over-screened International guidelines recommend that lung cancer patients usually undergo routine bronchoscopy, PET/CT, bone scanning and brain MRI before surgery. Prof. Haiquan Chen’s team confirmed in two prospective clinical studies that these investigations have no benefit in the treatment of ground-glass nodular lung cancer. This is an important distinction between “ground-glass nodular” lung cancer and conventional lung cancer,” Prof. Chen said. This study effectively streamlines the preoperative examination process for patients with MGNLC, reduces the trauma of invasive examinations, and reduces the medical burden on patients, while avoiding the waste of medical resources.