If the black spots on the glans are caused by congenital heredity, generally no drugs are needed. If it is caused by post-inflammatory hyperpigmentation and other diseases, it is necessary to apply topical drugs that inhibit the proliferation of black cells and drugs that inhibit tyrosine activity, such as azelaic acid and hydroquinone cream. 1. Physiological factors: If the congenital glans has black spots, and is not accompanied by physical discomfort symptoms, generally do not need to take drug treatment. In daily life, you need to keep the local skin clean and dry, and regular work and rest can be. 2. Post-inflammatory hyperpigmentation: black spots on the glans are also considered to be caused by post-inflammatory hyperpigmentation, patients can use topical inhibitors of melanocyte proliferation under the guidance of a doctor, such as azelaic acid, niacinamide, etc., or topical inhibitors of tyrosine activity drugs, such as hydroquinone cream, arbutin cream, etc. Most of the patients can fade after drug treatment. Most patients can lighten the black spots and improve the symptoms of the disease after drug treatment. There are many reasons that lead to black spots on the glans, and it is recommended that patients identify the causes of the disease in a timely manner and actively cooperate with the doctor to take relevant treatment measures, so as not to delay the condition.