Toothache after drinking wine may be caused by tooth sensitivity, acute pulpitis, apical periodontitis and so on. 1. Tooth sensitivity: patients with sensitive teeth will have toothache after drinking wine because alcohol is stimulating. In daily life, you need to avoid over-ice, hot and other stimulating foods to avoid the symptoms of toothache. 2. Acute pulpitis: the teeth themselves have inflammation, the stimulation of alcohol will lead to acute pulpitis attack, the patient will have symptoms of toothache. Acute pulpitis patients need to go to the regular hospital, by professional doctors to open the pulp drainage surgery, the pain will be significantly relieved. 3. Periapical periodontitis: Patients with periapical periodontitis will experience increased toothache after drinking alcohol, and need to follow the doctor’s instructions for root canal treatment and other ways to deal with it. It is recommended to go to the hospital as soon as possible to see a doctor to clarify the cause of the toothache after drinking wine, targeted treatment.