Pseudomembranous enteritis is also known as Clostridium difficile anaerobic bacterial enteritis, post-surgical enteritis, antibiotic enteritis, antibiotic-induced Clostridium difficile anaerobic bacterial enteritis, etc. PMC often occurs after major surgery and in patients with critical and chronic wasting disease. Pseudomembranous enteritis is an acute fibrinous exudative inflammation mainly occurring in the colon and small intestine, mostly caused by the application of antibiotics leading to the imbalance of normal intestinal flora, Clostridium difficile proliferation, the production of toxins and the disease . Because of the close relationship with the application of antibiotics is also known as “antibiotic-associated enteritis”, the disease occurs in the elderly, critically ill patients, immunocompromised and post-surgical patients, the clinical manifestations of its severity varies, can be only mild diarrhea, but also high fever, severe diarrhea, water and electrolyte disorders, toxic megacolon, and even life-threatening. life-threatening. The disease is serious and has a high mortality rate if treatment is not timely. Due to the widespread use of broad-spectrum antibiotics and immunosuppressive drugs, the incidence of this disease has a tendency to increase. Recent studies have confirmed that Clostridium difficile, isolated from the feces of pseudomembranous enteritis patients, produces cytotoxic toxins (Toxin B) and enterotoxic toxins (Toxin A), the former of which is an important pathogenetic factor in pseudomembranous enteritis. All of these toxins can cause lethal ileocecal enteritis in hamsters. The toxin can cause an increase in the permeability of the local intestinal mucosal vascular wall, resulting in tissue ischemia and necrosis, and stimulate the secretion of mucus, and inflammatory cells, such as the formation of pseudomembranes. In the feces of healthy people, the positive rate of Clostridium difficile is 5%, the carrying rate of hospitalized patients is about 13%, and the asymptomatic patients with clonus disease is about 8%. In the feces of 50% newborn babies and 15%-40% infants, although this bacterium can be isolated, and even toxin can be produced, but it does not have any pathogenic effect. General treatment 1, early diagnosis and timely treatment is extremely important to improve the cure rate and reduce mortality. Once diagnosed, the original antibiotic should be stopped immediately. 2.Supportive therapy: pay attention to rest. Infusion to correct water electrolyte disorders. Correct hypoproteinemia. In recent years, it is found that watery diarrhea caused by exomycin can be supplemented by oral glucose saline to replenish the loss of sodium chloride, and at the same time correct the acidosis. 3.Foster the normal intestinal flora to inhibit the growth of Clostridium difficile (fertile): usually with normal human feces 5 to 10g, mixed with 200ml saline, filtered and retained enema, 1 to 2 times a day for 3 to 5 days. Can also use cow’s milk enema containing lactobacillus or oral vitamin C and vitamin B, folic acid, lactase, glutamic acid and so on. 4, drug therapy: vancomycin and non-absorbable sulfonamides, effective treatment and prevention of experimental vole pseudomembranous enteritis and man-made pseudomembranous enteritis, can make the feces illegible (breeding) clostridial germ cells and their penicillin quickly disappear. Therefore, vancomycin is listed as the antibacterial drug of choice. Oral 250-500mg each time, 4 times a day.