Patients with chronic hepatitis B have a lower likelihood of appearing fully recovered and showing antigenic conversion regardless of their viral counts, and can achieve clinical cure with aggressive treatment. Hepatitis B virus below 500IU/ml indicates that the hepatitis B virus is controlled at a lower level, and if this level is detected without medication, there is a certain possibility of self-healing, but it is relatively low. If a hepatitis B patient has been taking antiviral medication for a long time and the hepatitis B virus is detected below 500 IU/ml, the low virus is due to the role played by the antiviral medication, and once the medication is discontinued the viral count will rebound. In this case, the likelihood of recovery from hepatitis B is extremely low. The severity of hepatitis B cannot be judged by the virus count alone, it needs to be integrated with liver function, liver ultrasound, non-invasive examination of liver fiber, etc. Most of the patients with hepatitis B can keep the virus count below the lower limit of detection through antiviral treatment, and the liver function is normal, which is known as the clinical cure, and only needs regular review, but it is still very difficult to realize the conversion of the surface antigen of hepatitis B into a negative one, and the complete cure.