For any kind of disease, a detailed diagnosis is the prerequisite for treatment, and it is also true for chronic renal failure. Chronic renal failure is one of the kidney diseases, because the disease has a great danger, so patients need to pay enough attention to this disease. So, how to diagnose chronic renal failure? Chronic renal failure has some of the following symptoms: First, the past history of the disease is unknown, sometimes need to be differentiated from acute renal failure, anemia, uremic face, hyperphosphatemia, hypocalcemia, elevated blood PTH concentration, double kidney shrinkage, support the diagnosis of this disease. Renal biopsy may be performed when needed. The underlying disease causing chronic energy renal failure should be investigated as much as possible. Secondly, the patient may feel unwell due to the accumulation of toxins and wastes in the body. Symptoms include nausea, vomiting, poor sleep at night, lack of appetite, itching and fatigue. Third, swelling, some patients may experience swelling. Decreased urine output and frequent urination (especially at night). Swelling of hands, feet and ankles. Other symptoms include shortness of breath and swelling around the eyes. Fourth, anemia, due to impaired kidney function, the body can not produce enough hormones needed to make red blood cells, thus producing anemia. People with anemia often feel cold and tired. Fifth, other symptoms, other symptoms of the disease, such as: hematuria (tea-colored or blood-red), high blood pressure, foam in the urine, diarrhea, extreme thirst, disturbed sleep, or lethargy, decreased libido and so on. Because of the slow onset of chronic renal failure, it leads to many patients being able to detect the disease in time, so that the best time to treat the disease is later delayed. A detailed diagnosis is crucial for patients with chronic renal failure, not only to avoid them from going into the wrong area of treatment, but also to help them better accept the treatment, I hope patients can take it seriously.