CPEO syndrome is a type of mitochondrial brain disease, and its main clinical manifestation is the gradual aggravation of extraocular muscle paralysis, and a small number of patients may be accompanied by limb weakness, lethargy or atrophy. 1. Gradual aggravation of extraocular muscle paralysis: patients will gradually develop drooping eyelids and limited eye movement. 2. Limb weakness: mainly manifested as weakness of limb muscles. 3. Wasting or atrophy: some patients may have difficulty in swallowing, leading to wasting and localized muscle atrophy. CPEO syndrome is a disease of muscle involvement due to mitochondrial structural or functional abnormalities. There is no effective cure, but only symptomatic supportive treatment with medication. After diagnosis, Coenzyme Q10 can be administered intramuscularly or orally under medical supervision to improve symptoms.