A 5 mm bulge at the base of the stomach may suggest inflammatory polyps or malignant tumors, which can be biopsied endoscopically and examined histopathologically. If submucosal masses are considered, ultrasonographic endoscopy is needed, and endoscopic mucosal dissection is performed if necessary. The presence of a bulge at the bottom of the stomach suggests the presence of organic changes, if it is caused by inflammatory polyps, usually endoscopic resection, and then need to be regularly reviewed to observe whether there is a recurrence of polyps and other situations. If it is caused by malignant tumors, when no metastasis occurs, partial or complete resection of the stomach is required, and lymphatic tissue should be cleared to prevent metastasis. If metastasis has occurred, after the clearance, you need to use chemotherapy or radiotherapy and other treatment modalities in conjunction. When the patient’s stomach bottom appears 5 mm bulge, need to consult a doctor in a timely manner, under the guidance of the doctor to carry out standardized treatment, do not blindly judge on their own.