Immunohistochemistry for lung cancer is a method of pathology-assisted diagnosis, which can be used for the determination of benign and malignant tumors; it helps in the pathologic typing of lung cancer patients, and also determines the origin of metastatic cancer.
1. Commonly used immunomarkers for lung cancer: TTF-1, NapsinA, CK7, alveolar surface glycoprotein (SP-A, SP-B), Cam5.2: positivity suggests lung adenocarcinoma.
2. Positive immunomarkers P40, P63, CK14, CK5/6, CK34βE12: suggesting squamous cell carcinoma of the lung.
3. Positive immune markers CgA, Syn, CD56: suggesting lung neuroendocrine tumor.
4. Other indicators: including H1R2, Kras or P53CK, suggesting that the tumor cells are of epithelial origin.
5. Ki67: it is a reliable marker of cell proliferation activity. The higher Ki67 is, the faster the tumor grows, the more invasive it is, and the higher the degree of malignancy.
Immunohistochemistry diagnosis can be more intuitive to the lesion site, degree, nature and source of the display, providing clinicians with an important basis for diagnosis and helping to formulate and optimize the subsequent treatment plan. It is recommended that patients choose appropriate diagnosis and treatment methods under the guidance of doctors, and actively treat the disease to avoid delays.