A patient with lumbar disc herniation treated with targeted radiofrequency ablation + O3 ablation + lateral saphenous fossa block. The duration of hospitalization was 5 days, with excellent results, and he was discharged. The patient’s right lower limb pain and numbness completely disappeared, and the right c-dorsal extension muscle strength recovered from grade 4 to grade 5. Conclusion: As long as the diagnosis is correct, the indications are chosen reasonably, and the correct minimally invasive method is selected, the efficacy of minimally invasive treatment of lumbar disc herniation is very precise, and the trauma is minimal, the recovery is fast, and the cost is not high. Case information: male, 78 years old, right lower extremity pain and numbness for 2+ months was admitted on 2011-05-21. 2+ months ago, the patient developed right lateral calf pain with no obvious cause, with persistent distension and numbness, the pain was aggravated by activity and cold, and alleviated by bed rest. He was admitted to the hospital for physical examination: claudication, no obvious deformity of the lumbar spine, no obvious restriction of lumbar spine movement, L3/4 and L4/5 interspinous pressure pain (+), no lower extremity radiating pain, left L3 transverse process pressure pain (++), pressure pain at the bilateral superior gluteal nerves (-), pressure pain at the body projection of the bilateral inferior foramen of the pear muscle (-), straight leg raise test R700 (+), L900 (-), supine erectile dystocia sign (+). The skin of the right lateral calf was slightly hyperalgesic with pain hypersensitivity. Bilateral knee tendon reflexes (++), bilateral Achilles tendon reflexes (++), right c-dorsal extension muscle strength grade 4, left grade 5, Barr’s sign (-). Lumbar spine CT showed: L3/4 and L4/5 disc bulge, L4/5 disc right posterior herniation; lumbar degenerative degeneration; osteoporosis. Minimally invasive surgery after: preoperative discussion comprehensive opinion: safe triangular approach to perform L4/5 discography, according to the imaging situation choose to perform disc decompression or target radiofrequency ablation + O3 ablation + lateral saphenous fossa block treatment. My personal opinion: medial margin approach with discography + targeted radiofrequency ablation + O3 ablation + lateral saphenous fossa block. Implementation: Safety triangle approach imaging showed that the annulus fibrosus was broken and the disc pressure was low, making it unsuitable for disc decompression. Instead, he was treated with a small intra-articular border puncture, targeted radiofrequency ablation + O3 ablation + lateral saphenous fossa block. Postoperative dehydration, nerve nutrition, improvement of microcirculation, and antibacterial agents to prevent infection were administered for 3 days. Recovery: On the first postoperative day, the patient was absolutely bedridden, and the pain was reduced by more than 50%. On the second postoperative day, the patient gradually got out of bed and was assisted by lumbar circumference when getting out of bed. On the 3rd postoperative day, the pain of the right lower limb completely disappeared, and the patient refused to continue observation for his own economic reasons and was discharged. Medical costs: The total charge should be more than 3900 yuan, because of the patient’s economic difficulties, the department gave a reduction of 1000 yuan (the patient really could not get money to settle the bill). Experience: Pre-operative judgment is very important to reduce detours; diagnosis must be clear, symptoms and imaging, signs consistent, segmental consistency, lateral consistency, exclude tuberculosis, tumors and other diseases that can cause similar symptoms; treatment methods should be carefully selected, carefully analyzed according to specific conditions, and develop the best treatment plan; strictly grasp the indications and contraindications of minimally invasive; puncture must be accurate, find the best target point and Puncture must be accurate, find the best target and puncture in place; radiofrequency temperature and time application are reasonable; postoperative rehabilitation guidance is also important, otherwise recovery is affected.