Cracking between the toes may be related to physiological factors such as dry skin, and secondly, it may be related to tinea pedis, palmoplantar pustulosis and other diseases, and it is recommended that patients take general treatment and medication to improve the situation. 1. Physiological factors: If the skin is too dry, it may cause local dehydration, peeling and cracking, so it is recommended to drink more water and apply moisturizing products daily. 2. Tinea pedis: cracking between the toes may be related to tinea pedis, patients should pay attention to foot cleaning, care, it is recommended that patients apply bifonazole, econazole and other antifungal drugs, which can improve the condition of the foot and inhibit the fungus. 3. Palmoplantar pustulosis: cracking between the toes may be triggered by palmoplantar pustulosis, patients should rest more, avoid wearing too tight shoes and socks. You can also use topical glucocorticoid drugs such as Halometasone and Hasinide to help anti-inflammatory and promote the recovery of skin lesions. The causes of cracking between the toes are more, after excluding physiological factors, patients are advised to consult a doctor for examination, to clarify the cause of the disease, and cooperate with the doctor for standardized treatment.