Pain medications for the treatment of ankylosing spondylitis can be broadly divided into the following categories: first, non-steroidal anti-inflammatory painkillers, represented by drugs such as ibuprofen extended-release capsules, celecoxib, diclofenac sodium tablets, loxoprofen and other drugs, the main role of anti-inflammatory pain relief, can be used to treat common ankylosing spondylitis pain, pain relief effect is relatively weak, but no addictive, so this type of drug is the most widely used, in general This type of drug is most widely used and can be bought in general hospitals or clinics. Second, central pain medications, including tramadol, are used to treat moderate pain. Third, narcotic painkillers, including morphine, pethidine and other opioids, have obvious pain-relieving effects, but long-term use of these drugs can have addictive symptoms, and require a prescription from a professional physician to take the drug. Fourth, the current widely used biological agents, on behalf of the drug beneficial Cypress, can quickly reduce inflammation and pain, and effectively relieve the development of the disease.