Fenofibrate belongs to the fibrate class of lipid-lowering drugs, which mainly lower triglycerides and also have a mild cholesterol-lowering effect. How long it takes to bring triglycerides down to normal after taking the drug is related to the patient’s physical condition, degree of illness, diet and underlying disease. Fenofibrate tablets, mainly for the treatment of adult patients with hyperlipidemia whose diet control therapy is not satisfactory, have the effect of lowering triglycerides and mixed hyperlipidemia, and the effect can be seen in 1-2 days of medication. After 2 weeks of taking the drug, the blood lipid situation will be reviewed and triglycerides can be significantly reduced. However, if the lipid-lowering effect is still poor after 2 months of continuous use, or the condition is even more serious, it is necessary to go to the endocrinology department of the hospital in time for a clear diagnosis and symptomatic treatment. In addition, pay attention to a low-salt and low-fat diet during taking the drug, quit smoking and alcohol, and take it together with food in order to reduce stomach discomfort. Regular monitoring of liver function and muscle enzymes, once sore calves and red urine are found, drug-induced rhabdomyolysis is highly suspected and prompt medical consultation to the emergency department or endocrinology is required.