Chemical liver injury refers to liver injury caused by alcohol, drugs, chemical toxic substances in the environment and so on. Liver is an important detoxification organ of human body, characterized by dual blood supply of hepatic artery and portal vein. Chemical substances can enter the liver through gastrointestinal tract, body circulation or portal vein and carry out bioconversion activities, so the liver is extremely vulnerable to damage by chemical substances, leading to the occurrence of chemical liver injury. The main clinical manifestations of chemical liver injury are pain in the liver area, nausea, vomiting, dyspepsia and loss of appetite, etc. Blood tests to check the liver function can be serum glutamic aminotransferase and other indicators of increase, suggesting that the liver cells are damaged. Harmful chemical substances lead to liver injury, can cause liver cell degeneration and necrosis, and in severe cases, acute liver failure may even occur. Therefore, after the occurrence of chemical liver injury, we should consult the doctor in time, and actively carry out the treatment, so as to avoid the aggravation of liver injury, which may lead to serious consequences.