Some patients with varicose veins in the lower extremities often say, “Doctor, I have vasculitis. In fact, varicose veins of lower extremities are not vasculitis. Simply speaking, vasculitis is an arterial disease, while varicose veins of lower extremities are a venous disease. Varicose veins in the lower extremities are commonly found in people who work in standing positions. They can develop in youth, and the prevalence generally increases after middle age. The affected limbs are easily fatigued, weak, swollen and heavy, sometimes with pain. The symptoms tend to appear when standing for long periods of time. The veins in the lower legs are commonly bulging, tortuous and dilated, and some of them are tortuous and form clusters of veins, which are obvious when standing. A few patients also have tortuous veins in the thighs. Varicose veins in the lower extremities cause stagnation of venous blood flow in the affected limbs. When the disease is longer, the affected limb tissue is hypoxic, metabolic waste collects, subcutaneous tissue fibrosis, and tissue resistance decreases. Once injury and infection occur, even if the injury is mild and can be healed quickly in normal people, it can cause long-lasting ulcers for varicose vein patients. Moreover, long-term metabolic waste aggregates and changes skin nutrition, and the affected limbs become pigmented, flaky, itchy, repeatedly irritated and form eczema. The diagnosis of varicose veins of lower limbs is not difficult according to clinical manifestations. Further understanding of deep vein reflux and venous valve function is needed before selecting the appropriate treatment. With the progress of social economy and people’s pursuit of high quality of life, patients with varicose veins in lower extremities should seek medical attention as early as possible to avoid complications such as ulcers and eczema and to improve the quality of life.