Adefovir combined with interferon is a common medication used for the treatment of hepatitis B, mainly for its antiviral effects. Adefovir and alpha-interferon have antiviral effects, and these two drugs are more effective drugs for HBeAg negative and have a certain effect on HBV-DNA negative, and are often used together in combination. These two drugs by effectively inhibiting viral replication, slowing down the progression of the disease, improve liver function, and then improve the prognosis. Adefovir tablets, as nucleoside analogs, are widely used because of their positive antiviral effects, as well as few adverse reactions and ease of administration. Adverse reactions include headache, abdominal pain, etc. It is prohibited for those who are allergic to this product. Alpha-interferon is recognized and most often used as the drug of choice for the treatment of chronic hepatitis B. It is moderately priced. The main adverse reactions include gastrointestinal discomfort such as nausea and vomiting as well as liver and kidney function impairment. It is contraindicated in people who are allergic to alpha-interferon. Adefovir combined with interferon must be used under the supervision of a physician.