By applying penicillin three times can control the disease development of syphilis patients to some extent, but whether it can completely kill syphilis can not be guaranteed, specific should be early, adequate and standardized treatment according to the doctor’s guidance, in order to have the possibility of cure. Syphilis can be clinically divided into early syphilis, late syphilis, according to the different stages, the treatment carried out, the time is different: 1, early syphilis: usually choose benzathine penicillin, or procaine penicillin for intramuscular injection treatment. And penicillin allergic person, need intravenous infusion of ceftriaxone, or oral doxycycline, tetracycline hydrochloride, minocycline, etc., have better treatment effect; 2, late syphilis: preferred benzathine penicillin intramuscular injection, or procaine penicillin, penicillin allergic person can take oral doxycycline. If the disease is not well controlled and the titer test result is persistently above 1:4, the treatment time should also be extended under the guidance of the doctor. Regular review is still required for three years after treatment, once every three months in the first year, once every six months in the second year, and once at the end of the third year to observe changes in titers. If the titer ratio decreases and does not recur, while excluding neurosyphilis and cardiovascular syphilis, it means that syphilis treatment is more effective and there is a possibility of complete cure. Syphilis patients who are not treated for a long time can develop multiple organ lesions and cause serious damage, so they should be treated actively. In addition, the sexual partners of syphilis patients should be examined and treated at the same time, and sexual intercourse is prohibited during the treatment period. In daily life, it is also important to maintain a positive attitude, strengthen personal hygiene, exercise properly to enhance physical fitness, and develop a healthy and regular diet and living habits.