Metronidazole tablets are usually combined with cephalosporin antibiotics such as cefuroxime and ceftriaxone to treat toothache. However, it is only used as an adjunctive treatment. Clinical diseases that lead to toothache are generally due to periodontal inflammation, the causes include gingivitis, pulpitis, apical inflammation, dental caries, wisdom teeth, etc., the treatment as an auxiliary need to anti-inflammatory anti-infective, usually choose metronidazole combined with cephalosporin antibiotics for the treatment of common cephalosporin antibiotics, such as cefuroxime, ceftriaxone, cephalopiperidin, etc., the pain is more severe, but also to take ibuprofen, diclofenac sodium and other medications for analgesia. When the pain is severe, you can also take ibuprofen, diclofenac sodium and other drugs for analgesia. It is recommended that patients with toothache symptoms, timely to the stomatology department, for gingivitis, pulpitis, apical inflammation, toothache caused by caries should be carried out in a timely manner periodontal treatment, root canal treatment, filling treatment. For toothache caused by wisdom teeth, tooth extraction can be chosen after anti-infection treatment. The above drugs should be used under the guidance of a doctor.