Treatment of sinus arrhythmias requires etiological treatment, in addition, antiarrhythmic drugs can be used. For sinus arrhythmias, antiarrhythmic drugs can be chosen from the class IB drug propafenone, and the class III drug amiodarone can be used. However, on the whole, the effect of class III drug amiodarone is better than class IB drug propafenone. Using amiodarone can effectively improve the cure rate of patients, improve their condition, reduce their pain, and also lower the probability of adverse reactions, so it can be considered to be promoted in clinical application. Sinus arrhythmia has the characteristics of rapid onset and great danger in pathological state, which manifests as panic, palpitation and syncope. Sinus arrhythmias also have the potential for secondary myocardial ischemia and even myocardial infarction, resulting in the development of a poor prognosis. Patients with sinus arrhythmia have increased myocardial oxygen consumption, resulting in decreased filling of the ventricles, which eventually leads to the occurrence of conditions such as reduced heart failure function.