Sinus rhythm T-wave alteration, in which sinus rhythm is a normal heart rate, and T-wave alteration suggests the possibility of myocardial ischemia and electrolyte disorders, etc. The first step is to clarify the cause of T-wave alteration formation. The medical history can be used to clarify whether the patient has related high-risk factors, such as hypertension, hyperlipidemia and hyperglycemia, and to clarify whether there are related symptoms, such as chest tightness, chest pain and other symptoms. For patients with related symptoms, it is recommended to give cardiac enzyme examination and, if necessary, coronary imaging to clarify the presence and degree of coronary artery stenosis. If necessary, interventional therapy or surgical coronary artery bypass grafting is given. In the case of T-wave changes due to cardiomyopathy, myocarditis, or electrolyte disorders, the corresponding treatment needs to be given.