Thyroid cysts are about 28mmx19mm, if the patient develops compression symptoms, he/she needs to take treatment, and common treatments include puncture and fluid extraction, drug sclerosis, radiofrequency ablation, and surgical treatment. Thyroid cysts 28mmx19mm are relatively large cysts, and if there is compression of nerves, blood vessels, trachea, esophagus, etc., thus causing the patient to experience symptoms such as coughing, shortness of breath, difficulty in swallowing, etc., measures need to be taken for treatment. Patients can be treated with simple puncture and fluid extraction under ultrasound guidance, and they can also be treated with puncture sclerosis and radiofrequency ablation. If the effect of the above treatments is not obvious, patients need to be treated with thyroid cystectomy under the guidance of a doctor. It is recommended that patients with thyroid cysts of about 28mmx19mm should consult a doctor in time, and the doctor will choose targeted measures according to the patient’s condition.