When a person’s gallbladder breaks down, it is clinically known as gallbladder perforation, and gallbladder perforation should be treated aggressively with surgery. Gallbladder perforation is a serious complication of biliary tract diseases and is treated surgically as soon as it is diagnosed and after active preoperative preparation. The mode of surgical treatment is related to the patient’s general condition, the type of pathological changes and the extent of the lesion. If the local inflammation is not severe and the general condition is good, cholecystectomy can be performed to completely remove the abdominal pus. If the condition is critical or the local inflammation is significant, after removing the abdominal pus, cholecystostomy can be performed temporarily, and then elective surgery can be performed to remove the gallbladder after the systemic and local conditions improve. If the etiology cannot be clarified, choledochotomy exploration and T-tube drainage can be performed. After surgery, one should pay attention to light diet, forbid cold, spicy, greasy food, avoid overwork and mental stress, and consult a doctor if there is any discomfort.