Large blisters after freezing may be frostbite caused by the low temperature of the skin during liquid nitrogen cryotherapy. Treatment includes life care, medication and fluid extraction, etc. However, it takes time for the blisters to subside, so avoid over-pursuing the so-called fast treatment methods. 1. Life care: avoid squeezing the blisters with your hands in the near future, so as not to rupture the blisters, bacteria invasion, causing secondary infection. 2. medication: if the blister has ruptured, you need to disinfect the area, and at the same time, use gauze to bandage the area to avoid infection, if necessary, oral cefixime, amoxicillin and other drugs anti-infection treatment. 3. Extraction of fluid: If the large blister is accompanied by obvious pain and has not yet ruptured, but may rupture at any time, the fluid inside the blister needs to be extracted. During the treatment, the doctor will pierce the blister with an empty, sterilized needle to remove all the fluid inside, and then disinfect the blister with iodine povidone. It is recommended that the patient inform the doctor of the symptoms and follow the doctor’s instructions, not to treat the blisters or use any medication.